Detection of glycoprotein of Burkholderia pseudomallei.

and the one presented by Jiang (5) suggest that both the SDF-1 chemokine and the V3 loop of Ttropic HIV-1 viruses use positively charged amino acids for an electrostatic interaction with the negatively charged CXCR4 receptor. To examine whether the similarity between the chemokine and env V3 domain is also apparent at the primary sequence level, we performed an amino acid alignment; however, we found no conserved motifs (data not shown). A detailed mutational analysis is required to further our understanding of the env-coreceptor interaction.